New Insights into the Pathogenesis of Alcohol-Induced ER Stress and Liver Diseases
Author
Source
International Journal of Hepatology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Alcohol-induced liver disease increasingly contributes to human mortality worldwide.
Alcohol-induced endoplasmic reticulum (ER) stress and disruption of cellular protein homeostasis have recently been established as a significant mechanism contributing to liver diseases.
The alcohol-induced ER stress occurs not only in cultured hepatocytes but also in vivo in the livers of several species including mouse, rat, minipigs, zebrafish, and humans.
Identified causes for the ER stress include acetaldehyde, oxidative stress, impaired one carbon metabolism, toxic lipid species, insulin resistance, disrupted calcium homeostasis, and aberrant epigenetic modifications.
Importance of each of the causes in alcohol-induced liver injury depends on doses, duration and patterns of alcohol exposure, genetic disposition, environmental factors, cross-talks with other pathogenic pathways, and stages of liver disease.
The ER stress may occur more or less all the time during alcohol consumption, which interferes with hepatic protein homeostasis, proliferation, and cell cycle progression promoting development of advanced liver diseases.
Emerging evidence indicates that long-term alcohol consumption and ER stress may directly be involved in hepatocellular carcinogenesis (HCC).
Dissecting ER stress signaling pathways leading to tumorigenesis will uncover potential therapeutic targets for intervention and treatment of human alcoholics with liver cancer.
American Psychological Association (APA)
Ji, Cheng. 2014. New Insights into the Pathogenesis of Alcohol-Induced ER Stress and Liver Diseases. International Journal of Hepatology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-477636
Modern Language Association (MLA)
Ji, Cheng. New Insights into the Pathogenesis of Alcohol-Induced ER Stress and Liver Diseases. International Journal of Hepatology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-477636
American Medical Association (AMA)
Ji, Cheng. New Insights into the Pathogenesis of Alcohol-Induced ER Stress and Liver Diseases. International Journal of Hepatology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-477636
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477636