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The Role of CTLA-4 Exon-1 49 AG Polymorphism and Soluble CTLA-4 Protein Level in Egyptian Patients with Behçet's Disease
Joint Authors
Hagrass, Hoda A.
Abdel Galil, Sahar M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study analyzed the association of the A/G SNP at position +49 of exon-1 in the CTLA-4 gene to the susceptibility and clinical manifestations of Behcet’s disease (BD).
It was performed on 60 Egyptian BD patients and 95 age- and sex-matched healthy controls.
The genotypes for the +49 A/G polymorphism of the CTLA-4 gene were determined by PCR-RFLP, while the serum level of CTLA-4 protein was measured by ELISA.
CTLA-4 +49 A allele (P<0.001, OR=3.084, and CI (95%) = 1.90–4.99) and A/A genotype (P<0.001, OR=6.643, and CI (95%) = 2.58–17.10) frequency distribution was significantly more increased in patients than in the controls, with no significant differences between males and females with regard to the genotype or allele frequency distribution.
A/A genotype was associated with a more reduced expression of sCTLA-4 protein in patients than in the controls (1.76±0.19 versus 1.91±0.30, resp; P<0.0007).
In addition, it is associated with the occurrence of ocular and vasculitic manifestations of BD in the patient group.
The CTLA-4 gene could be considered as a susceptibility and a disease-modifying gene to BD in Egyptian population that needs further confirmatory studies on larger cohorts.
American Psychological Association (APA)
Abdel Galil, Sahar M.& Hagrass, Hoda A.. 2014. The Role of CTLA-4 Exon-1 49 AG Polymorphism and Soluble CTLA-4 Protein Level in Egyptian Patients with Behçet's Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-477653
Modern Language Association (MLA)
Abdel Galil, Sahar M.& Hagrass, Hoda A.. The Role of CTLA-4 Exon-1 49 AG Polymorphism and Soluble CTLA-4 Protein Level in Egyptian Patients with Behçet's Disease. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-477653
American Medical Association (AMA)
Abdel Galil, Sahar M.& Hagrass, Hoda A.. The Role of CTLA-4 Exon-1 49 AG Polymorphism and Soluble CTLA-4 Protein Level in Egyptian Patients with Behçet's Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-477653
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477653