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PPAR Gamma Activators : Off-Target Against Glioma Cell Migration and Brain Invasion
Joint Authors
Zlotos, Darius P.
Blümcke, Ingmar
Seufert, Sebastian
Hahnen, Eric
Heneka, Michael T.
Tatenhorst, Lars
Tränkle, Christian
Coras, Roland
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-09-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Today, there is increasing evidence that PPARγ agonists, including thiazolidinediones (TDZs) and nonthiazolidinediones, block the motility and invasiveness of glioma cells and other highly migratory tumor entities.
However, the mechanism(s) by which PPARγ activators mediate their antimigratory and anti-invasive properties remains elusive.
This letter gives a short review on the debate and adds to the current knowledge by applying a PPARγ inactive derivative of the TDZ troglitazone (Rezulin) which potently counteracts experimental glioma progression in a PPARγ independent manner.
American Psychological Association (APA)
Seufert, Sebastian& Coras, Roland& Tränkle, Christian& Zlotos, Darius P.& Blümcke, Ingmar& Tatenhorst, Lars…[et al.]. 2008. PPAR Gamma Activators : Off-Target Against Glioma Cell Migration and Brain Invasion. PPAR Research،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-477657
Modern Language Association (MLA)
Seufert, Sebastian…[et al.]. PPAR Gamma Activators : Off-Target Against Glioma Cell Migration and Brain Invasion. PPAR Research No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-477657
American Medical Association (AMA)
Seufert, Sebastian& Coras, Roland& Tränkle, Christian& Zlotos, Darius P.& Blümcke, Ingmar& Tatenhorst, Lars…[et al.]. PPAR Gamma Activators : Off-Target Against Glioma Cell Migration and Brain Invasion. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-477657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477657