Release of Inflammatory Mediators by Human Adipose Tissue Is Enhanced in Obesity and Primarily by the Nonfat Cells : A Review
Author
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-23
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
This paper considers the role of putative adipokines that might be involved in the enhanced inflammatory response of human adipose tissue seen in obesity.
Inflammatory adipokines [IL-6, IL-10, ACE, TGFβ1, TNFα, IL-1β, PAI-1, and IL-8] plus one anti-inflammatory [IL-10] adipokine were identified whose circulating levels as well as in vitro release by fat are enhanced in obesity and are primarily released by the nonfat cells of human adipose tissue.
In contrast, the circulating levels of leptin and FABP-4 are also enhanced in obesity and they are primarily released by fat cells of human adipose tissue.
The relative expression of adipokines and other proteins in human omental as compared to subcutaneous adipose tissue as well as their expression in the nonfat as compared to the fat cells of human omental adipose tissue is also reviewed.
The conclusion is that the release of many inflammatory adipokines by adipose tissue is enhanced in obese humans.
American Psychological Association (APA)
Fain, John N.. 2010. Release of Inflammatory Mediators by Human Adipose Tissue Is Enhanced in Obesity and Primarily by the Nonfat Cells : A Review. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-20.
https://search.emarefa.net/detail/BIM-477658
Modern Language Association (MLA)
Fain, John N.. Release of Inflammatory Mediators by Human Adipose Tissue Is Enhanced in Obesity and Primarily by the Nonfat Cells : A Review. Mediators of Inflammation No. 2010 (2010), pp.1-20.
https://search.emarefa.net/detail/BIM-477658
American Medical Association (AMA)
Fain, John N.. Release of Inflammatory Mediators by Human Adipose Tissue Is Enhanced in Obesity and Primarily by the Nonfat Cells : A Review. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-20.
https://search.emarefa.net/detail/BIM-477658
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477658