Simulation of Drug Release from PLGA Particles In Vivo
Joint Authors
Komori, Yuna
Fukushima, Kouhei
Hinata, Manami
Igarashi, Martha
Sasaki, Kaori
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Specific targeting of tissues and/or cells is essential for any type of drug delivery system because this determines the efficacy and side effects of the drug.
Poly lactic-co-glycolic acids (PLGA) have long been used as biomaterials for drug delivery due to their excellent biocompatibility and biodegradability.
Direct visualization of PLGA particles is feasible even within tissues, and cell specificity of the drug delivery system is normally assessed by using labeled particles.
However, particle labeling alone does not address factors such as the release and distribution of the drug.
Thus, it is desirable to set up a simulation system of drug release and distribution in vivo.
In the present study, we aimed to establish a method to simulate drug distribution in PLGA drug delivery by using Hoechst 33342 as an imitating drug.
Our approach enabled us to identify, isolate, and characterize cells exposed to Hoechst 33342 and to deduce the concentration of this fluorescent dye around both targeted and nontargeted cells.
We believe that the method described herein will provide essential information regarding the specificity of cell targeting in any type of PLGA drug delivery system.
American Psychological Association (APA)
Sasaki, Kaori& Igarashi, Martha& Hinata, Manami& Komori, Yuna& Fukushima, Kouhei. 2013. Simulation of Drug Release from PLGA Particles In Vivo. Journal of Drug Delivery،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-477659
Modern Language Association (MLA)
Sasaki, Kaori…[et al.]. Simulation of Drug Release from PLGA Particles In Vivo. Journal of Drug Delivery No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-477659
American Medical Association (AMA)
Sasaki, Kaori& Igarashi, Martha& Hinata, Manami& Komori, Yuna& Fukushima, Kouhei. Simulation of Drug Release from PLGA Particles In Vivo. Journal of Drug Delivery. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-477659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477659