HPV Type Distribution and Cervical Cytology among HIV-Positive Tanzanian and South African Women
Joint Authors
Brown, Joelle M.
Tempelman, Hugo A.
Reid, Gregor
Dols, Joke A. M.
Bontekoe, Tj. Romke
Boon, Mathilde E.
Quint, Wim G. V.
Source
ISRN Obstetrics and Gynecology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
There are limited data on high-risk human papillomavirus (hr-HPV) genotypes among HIV-positive women in Africa, and little is known about their relationship with cervical cytology in these populations.
Methods.
We conducted a cross-sectional study among 194 HIV-positive women (143 from Tanzania, and 51 from South Africa) to evaluate HPV genotypes among HIV-positive women with normal and abnormal cytology.
Cervical samples were genotyped for HPV types, and slides were evaluated for atypical squamous cell changes according to the Bethesda classification system.
Results.
Prevalence of high grade squamous intraepithelial dysplasia (HSIL) was 9%.
Overall, more than half (56%) of women were infected with an hr-HPV type; 94% of women with HSIL (n=16), 90% of women with LSIL (n=35), and 42% of women within normal limits (WNL) (n=58) tested positive for hr-HPV.
Overall, the most prevalent hr-HPV subtypes were HPV16 (26%) and HPV52 (30%).
Regional differences in the prevalence of HPV18 and HPV35 were found.
Conclusion.
Regional differences in HPV genotypes among African women warrant the need to consider different monitoring programmes for cervical preneoplasia.
HPV-based screening tests for cervical preneoplasia would be highly inefficient unless coupled with cytology screening of the HPV-positive sample, especially in HIV-positive women.
American Psychological Association (APA)
Dols, Joke A. M.& Reid, Gregor& Brown, Joelle M.& Tempelman, Hugo A.& Bontekoe, Tj. Romke& Quint, Wim G. V.…[et al.]. 2012. HPV Type Distribution and Cervical Cytology among HIV-Positive Tanzanian and South African Women. ISRN Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-477678
Modern Language Association (MLA)
Dols, Joke A. M.…[et al.]. HPV Type Distribution and Cervical Cytology among HIV-Positive Tanzanian and South African Women. ISRN Obstetrics and Gynecology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-477678
American Medical Association (AMA)
Dols, Joke A. M.& Reid, Gregor& Brown, Joelle M.& Tempelman, Hugo A.& Bontekoe, Tj. Romke& Quint, Wim G. V.…[et al.]. HPV Type Distribution and Cervical Cytology among HIV-Positive Tanzanian and South African Women. ISRN Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-477678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477678