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The Role of Dysregulated Glucose Metabolism in Epithelial Ovarian Cancer
Joint Authors
Kellenberger, L. D.
Moorehead, R. A.
Campbell, N. E.
Greenaway, J.
Petrik, J.
Bruin, J. E.
Holloway, Alison C.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer and also one of the most poorly understood.
Other health issues that are affecting women with increasing frequency are obesity and diabetes, which are associated with dysglycemia and increased blood glucose.
The Warburg Effect describes the ability of fast-growing cancer cells to preferentially metabolize glucose via anaerobic glycolysis rather than oxidative phosphorylation.
Recent epidemiological studies have suggested a role for hyperglycemia in the pathogenesis of a number of cancers.
If hyperglycemia contributes to tumour growth and progression, then it is intuitive that antihyperglycemic drugs may also have an important antitumour role.
Preliminary reports suggest that these drugs not only reduce available plasma glucose, but also have direct effects on cancer cell viability through modification of molecular energy-sensing pathways.
This review investigates the effect that hyperglycemia may have on EOC and the potential of antihyperglycemic drugs as therapeutic adjuncts.
American Psychological Association (APA)
Kellenberger, L. D.& Bruin, J. E.& Greenaway, J.& Campbell, N. E.& Moorehead, R. A.& Holloway, Alison C.…[et al.]. 2010. The Role of Dysregulated Glucose Metabolism in Epithelial Ovarian Cancer. Journal of Oncology،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-477695
Modern Language Association (MLA)
Kellenberger, L. D.…[et al.]. The Role of Dysregulated Glucose Metabolism in Epithelial Ovarian Cancer. Journal of Oncology No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-477695
American Medical Association (AMA)
Kellenberger, L. D.& Bruin, J. E.& Greenaway, J.& Campbell, N. E.& Moorehead, R. A.& Holloway, Alison C.…[et al.]. The Role of Dysregulated Glucose Metabolism in Epithelial Ovarian Cancer. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-477695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477695