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Oxidative Stress and Inflammation in Heart Disease : Do Antioxidants Have a Role in Treatment andor Prevention?
Source
International Journal of Inflammation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inflammation triggered by oxidative stress is the cause of much, perhaps even most, chronic human disease including human aging.
The oxidative stress originates mainly in mitochondria from reactive oxygen and reactive nitrogen species (ROS/RNS) and can be identified in most of the key steps in the pathophysiology of atherosclerosis and the consequential clinical manifestations of cardiovascular disease.
In addition to the formation of atherosclerosis, it involves lipid metabolism, plaque rupture, thrombosis, myocardial injury, apoptosis, fibrosis and failure.
The recognition of the critical importance of oxidative stress has led to the enthusiastic use of antioxidants in the treatment and prevention of heart disease, but the results of prospective, randomized clinical trials have been overall disappointing.
Can this contradiction be explained and what are its implications for the discovery/development of future antioxidant therapeutics?
American Psychological Association (APA)
2011. Oxidative Stress and Inflammation in Heart Disease : Do Antioxidants Have a Role in Treatment andor Prevention?. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-477718
Modern Language Association (MLA)
Oxidative Stress and Inflammation in Heart Disease : Do Antioxidants Have a Role in Treatment andor Prevention?. International Journal of Inflammation No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-477718
American Medical Association (AMA)
Oxidative Stress and Inflammation in Heart Disease : Do Antioxidants Have a Role in Treatment andor Prevention?. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-477718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477718