Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction
Joint Authors
Korokin, Mihail V.
Dudina, Eleonora N.
Konovalova, Elena A.
Terehova, Elena G.
Korokina, Liliya V.
Tsepeleva, Svetlana A.
Babko, Anna V.
Pokrovskiy, Mihail V.
Gureev, Vladimir V.
Gudyrev, Oleg S.
Kochkarov, Vladimir I.
Pokrovskaya, Tatyana G.
Source
International Journal of Hypertension
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
This paper is about a way of correction of endothelial dysfunction with the inhibitor of arginase: L-norvaline.
There is an imbalance between vasoconstriction and vasodilatation factors of endothelium on the basis of endothelial dysfunction.
Among vasodilatation agents, nitrogen oxide plays the basic role.
Amino acid L-arginine serves as a source of molecules of nitrogen oxide in an organism.
Because of the high activity of arginase enzyme which catalyzes the hydrolysis of L-arginine into ornithine and urea, the bioavailability of nitrogen oxide decreases.
The inhibitors of arginase suppress the activity of the given enzyme, raising and production of nitrogen oxide, preventing the development of endothelial dysfunction.
American Psychological Association (APA)
Pokrovskiy, Mihail V.& Korokin, Mihail V.& Tsepeleva, Svetlana A.& Pokrovskaya, Tatyana G.& Gureev, Vladimir V.& Konovalova, Elena A.…[et al.]. 2011. Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction. International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-477764
Modern Language Association (MLA)
Pokrovskiy, Mihail V.…[et al.]. Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction. International Journal of Hypertension No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-477764
American Medical Association (AMA)
Pokrovskiy, Mihail V.& Korokin, Mihail V.& Tsepeleva, Svetlana A.& Pokrovskaya, Tatyana G.& Gureev, Vladimir V.& Konovalova, Elena A.…[et al.]. Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction. International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-477764
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477764