Cytokines in the Progression of Pancreatic β-Cell Dysfunction
Joint Authors
Guan, Youfei
Yang, Jichun
Wang, Chunjiong
Source
International Journal of Endocrinology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The dysfunction of pancreatic β-cell and the reduction in β-cell mass are the decisive events in the progression of type 2 diabetes.
There is increasing evidence that cytokines play important roles in the procedure of β-cell failure.
Cytokines, such as IL-1β, IFN-γ, TNF-α, leptin, resistin, adiponectin, and visfatin, have been shown to diversely regulate pancreatic β-cell function.
Recently, islet-derived cytokine PANcreatic DERived factor (PANDER or FAM3B) has also been demonstrated to be a regulator of islet β-cell function.
The change in cytokine profile in islet and plasma is associated with pancreatic β-cell dysfunction and apoptosis.
In this paper, we summarize and discuss the recent studies on the effects of certain important cytokines on pancreatic β-cell function.
The imbalance in deleterious and protective cytokines plays pivotal roles in the development and progression of pancreatic β-cell dysfunction under insulin-resistant conditions.
American Psychological Association (APA)
Wang, Chunjiong& Guan, Youfei& Yang, Jichun. 2010. Cytokines in the Progression of Pancreatic β-Cell Dysfunction. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-477773
Modern Language Association (MLA)
Wang, Chunjiong…[et al.]. Cytokines in the Progression of Pancreatic β-Cell Dysfunction. International Journal of Endocrinology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-477773
American Medical Association (AMA)
Wang, Chunjiong& Guan, Youfei& Yang, Jichun. Cytokines in the Progression of Pancreatic β-Cell Dysfunction. International Journal of Endocrinology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-477773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477773