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Evaluation of Traditional Indian Antidiabetic Medicinal Plants for Human Pancreatic Amylase Inhibitory Effect In Vitro
Joint Authors
Zinjarde, Smita S.
Ravindran, Remya
Ponnusamy, Sudha
Ravi Kumar, Ameeta
Bhargava, Shobha Y.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post prandial hyperglycemia via control of starch breakdown.
Eleven Ayurvedic Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory potential on pancreatic α-amylase.
Analysis of 91 extracts, showed that 10 exhibited strong Human Pancreatic Amylase (HPA) inhibitory potential.
Of these, 6 extracts showed concentration dependent inhibition with IC50 values, namely, cold and hot water extracts from Ficus bengalensis bark (4.4 and 125 μgmL-1), Syzygium cumini seeds (42.1 and 4.1 μgmL-1), isopropanol extracts of Cinnamomum verum leaves (1.0 μgmL-1) and Curcuma longa rhizome (0.16 μgmL-1).
The other 4 extracts exhibited concentration independent inhibition, namely, methanol extract of Bixa orellana leaves (49 μgmL-1), isopropanol extract from Murraya koenigii leaves (127 μgmL-1), acetone extracts from C.
longa rhizome (7.4 μgmL-1) and Tribulus terrestris seeds (511 μgmL-1).
Thus, the probable mechanism of action of the above fractions is due to their inhibitory action on HPA, thereby reducing the rate of starch hydrolysis leading to lowered glucose levels.
Phytochemical analysis revealed the presence of alkaloids, proteins, tannins, cardiac glycosides, flavonoids, saponins and steroids as probable inhibitory compounds.
American Psychological Association (APA)
Ponnusamy, Sudha& Ravindran, Remya& Zinjarde, Smita S.& Bhargava, Shobha Y.& Ravi Kumar, Ameeta. 2010. Evaluation of Traditional Indian Antidiabetic Medicinal Plants for Human Pancreatic Amylase Inhibitory Effect In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-477800
Modern Language Association (MLA)
Ponnusamy, Sudha…[et al.]. Evaluation of Traditional Indian Antidiabetic Medicinal Plants for Human Pancreatic Amylase Inhibitory Effect In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-477800
American Medical Association (AMA)
Ponnusamy, Sudha& Ravindran, Remya& Zinjarde, Smita S.& Bhargava, Shobha Y.& Ravi Kumar, Ameeta. Evaluation of Traditional Indian Antidiabetic Medicinal Plants for Human Pancreatic Amylase Inhibitory Effect In Vitro. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-477800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477800