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HIV RNA Suppression and Immune Restoration : Can We Do Better?
Joint Authors
Di Rosa, Michelino
Cacopardo, Bruno
Pinzone, Marilia Rita
Nunnari, Giuseppe
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
HAART has significantly changed the natural history of HIV infection: patients receiving antiretrovirals are usually able to control viremia, even though not all virological responders adequately recover their CD4+ count.
The reasons for poor immune restoration are only partially known and they include genetic, demographic and immunologic factors.
A crucial element affecting immune recovery is immune activation, related to residual viremia; indeed, a suboptimal virological control (i.e., low levels of plasma HIV RNA) has been related with higher levels of chronic inflammation and all-cause mortality.
The sources of residual viremia are not yet completely known, even though the most important one is represented by latently infected cells.
Several methods, including 2-LTR HIV DNA and unspliced HIV RNA measurement, have been developed to estimate residual viremia and predict the outcome of antiretroviral therapy.
Considering that poor immunologic responders are exposed to a higher risk of both AIDS-related and non-AIDS-related diseases, there is a need of new therapeutic strategies, including immunomodulators and drugs targeting the latent viral reservoirs, in order to face residual viremia but also to “drive” the host immunologic responses.
American Psychological Association (APA)
Pinzone, Marilia Rita& Di Rosa, Michelino& Cacopardo, Bruno& Nunnari, Giuseppe. 2012. HIV RNA Suppression and Immune Restoration : Can We Do Better?. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-477833
Modern Language Association (MLA)
Pinzone, Marilia Rita…[et al.]. HIV RNA Suppression and Immune Restoration : Can We Do Better?. Clinical and Developmental Immunology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-477833
American Medical Association (AMA)
Pinzone, Marilia Rita& Di Rosa, Michelino& Cacopardo, Bruno& Nunnari, Giuseppe. HIV RNA Suppression and Immune Restoration : Can We Do Better?. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-477833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477833