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Endothelin but Not Angiotensin II May Mediate Hypertension-Induced Coronary Vascular Calcification in Chronic Kidney Disease
Author
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
To understand the relationship between putative neurohormonal factors operative in hypertension and coronary artery calcification (CAC), the relevant cellular actions of angiotensin (Ang II) and endothelin-1 (ET-1) are reviewed.
There is compelling evidence to implicate ET-1 in CAC.
ET-1 increases phosphate transport with a 42 to 73% increase in Vmax.
Increased cellular phosphate may induce CAC through increased Ca x phosphate product, transformation of vascular smooth muscle cells into a bone-producing phenotype or cell apoptosis that releases procalcific substances.
ET-1 is increased in several models of vascular calcification.
ET-1 inhibits inhibitors of calcification, matrix Gla and osteoprotegerin, while enhancing pro-calcific factors such as BMP-2 and osteopontin.
In contrast, Ang II inhibits phosphate transport decreasing Vmax by 38% and increases matrix Gla.
Ang II also stimulates bone resorption.
Vascular calcification is reduced by ET-1 A receptor antagonists and to a greater extent than angiotensin receptor blockade although both agents reduce blood pressure.
American Psychological Association (APA)
Rabkin, Simon W.. 2011. Endothelin but Not Angiotensin II May Mediate Hypertension-Induced Coronary Vascular Calcification in Chronic Kidney Disease. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-477859
Modern Language Association (MLA)
Rabkin, Simon W.. Endothelin but Not Angiotensin II May Mediate Hypertension-Induced Coronary Vascular Calcification in Chronic Kidney Disease. International Journal of Nephrology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-477859
American Medical Association (AMA)
Rabkin, Simon W.. Endothelin but Not Angiotensin II May Mediate Hypertension-Induced Coronary Vascular Calcification in Chronic Kidney Disease. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-477859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477859