The Amphiphilic Self-Assembling Peptide EAK16-I as a Potential Hydrophobic Drug Carrier
Joint Authors
Wang, Jing
Tang, Fushan
Lin, Juan
Li, Feng
Zhao, Xiaojun
Du, Linfang
Zhang, Yinghui
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-07-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
It is crucial for hydrophobic drugs to be dissolved and stabilized by carriers in aqueous systems and then to be delivered into target cells.
An amphiphilic self-assembling peptide EAK16-I (Ac-AEAKAEAKAEAKAEAK-NH2) is reported here to be able to stabilize a model hydrophobic compound, pyrene, in aqueous solution, resulting in the formation of colloidal suspensions.
Egg phosphatidylcholine (EPC) vesicles are used as plasma membranes mimic.
Fluorescence data shows that the pyrene is presented in the crystalline form when stabilized by EAK16-I and molecularly migrates from its peptide encapsulations into the membrane bilayers of EPC vesicles when the suspension is mixed with EPC vesicles.
Furthermore, the release rate can be controlled by changing peptide-to-pyrene ratio, and the higher ratios lead to the slower release rates due to a thicker encapsulation on the pyrene microcrystals.
This demonstrates that EAK16-I, as a promising nanobiomaterial, has the potential to be a hydrophobic compounds carrier.
American Psychological Association (APA)
Wang, Jing& Tang, Fushan& Li, Feng& Lin, Juan& Zhang, Yinghui& Du, Linfang…[et al.]. 2008. The Amphiphilic Self-Assembling Peptide EAK16-I as a Potential Hydrophobic Drug Carrier. Journal of Nanomaterials،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-477864
Modern Language Association (MLA)
Wang, Jing…[et al.]. The Amphiphilic Self-Assembling Peptide EAK16-I as a Potential Hydrophobic Drug Carrier. Journal of Nanomaterials No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-477864
American Medical Association (AMA)
Wang, Jing& Tang, Fushan& Li, Feng& Lin, Juan& Zhang, Yinghui& Du, Linfang…[et al.]. The Amphiphilic Self-Assembling Peptide EAK16-I as a Potential Hydrophobic Drug Carrier. Journal of Nanomaterials. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-477864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477864