Behavioral Consequences of Delta-Opioid Receptor Activation in the Periaqueductal Gray of Morphine Tolerant Rats
Joint Authors
Christie, MacDonald J.
Ingram, Susan L.
Ashley, Michelle D.
Morgan, Michael M.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-02-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Chronic morphine administration shifts delta-opioid receptors (DORs) from the cytoplasm to the plasma membrane.
Given that microinjection of morphine into the PAG produces antinociception, it is hypothesized that the movement of DORs to the membrane will allow antinociception to the DOR agonist deltorphin II as a way to compensate for morphine tolerance.
Tolerance was induced by twice daily injections of morphine (5, 10, or 20 mg/kg, subcutaneous) for 3.5 days.
Microinjection of deltorphin into the vPAG 6 hours after the last morphine injection produced a mild antinociception that did not vary in a consistent manner across morphine pretreatment doses or nociceptive tests.
In contrast, deltorphin caused a decrease in activity in morphine tolerant rats that was associated with lying in the cage.
The decrease in activity and change in behavior indicate that chronic morphine administration alters DORs in the vPAG.
However, activation of these receptors does not appear to compensate for the decrease in antinociception caused by morphine tolerance.
American Psychological Association (APA)
Morgan, Michael M.& Ashley, Michelle D.& Ingram, Susan L.& Christie, MacDonald J.. 2009. Behavioral Consequences of Delta-Opioid Receptor Activation in the Periaqueductal Gray of Morphine Tolerant Rats. Neural Plasticity،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-477869
Modern Language Association (MLA)
Morgan, Michael M.…[et al.]. Behavioral Consequences of Delta-Opioid Receptor Activation in the Periaqueductal Gray of Morphine Tolerant Rats. Neural Plasticity No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-477869
American Medical Association (AMA)
Morgan, Michael M.& Ashley, Michelle D.& Ingram, Susan L.& Christie, MacDonald J.. Behavioral Consequences of Delta-Opioid Receptor Activation in the Periaqueductal Gray of Morphine Tolerant Rats. Neural Plasticity. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-477869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477869