DNA Loci Cross-Talk through Thermodynamics
Joint Authors
Scialdone, Antonio
Nicodemi, Mario
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The recognition and pairing of specific DNA loci, though crucial for a plenty of important cellular processes, are produced by still mysterious physical mechanisms.
We propose the first quantitative model from Statistical Mechanics, able to clarify the interaction allowing such “DNA cross-talk” events.
Soluble molecules, which bind some DNA recognition sequences, produce an effective attraction between distant DNA loci; if their affinity, their concentration, and the relative DNA binding sites number exceed given thresholds, DNA colocalization occurs as a result of a thermodynamic phase transition.
In this paper, after a concise report on some of the most recent experimental results, we introduce our model and carry out a detailed “in silico” analysis of it, by means of Monte Carlo simulations.
Our studies, while rationalize several experimental observations, result in very interesting and testable predictions.
American Psychological Association (APA)
Scialdone, Antonio& Nicodemi, Mario. 2009. DNA Loci Cross-Talk through Thermodynamics. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-477907
Modern Language Association (MLA)
Scialdone, Antonio& Nicodemi, Mario. DNA Loci Cross-Talk through Thermodynamics. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-477907
American Medical Association (AMA)
Scialdone, Antonio& Nicodemi, Mario. DNA Loci Cross-Talk through Thermodynamics. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-477907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477907