Hepatoportal Leptin Sensors and Their Reflex Effects on Autonomic Outflow in the Rat
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Afferent nerve signals were recorded from a peripheral cut end of the small nerve bundle of the hepatic branch of the vagus nerve in anesthetized rats.
An injection of leptin (100 pg, 0.1 mL) into the portal vein facilitated the afferent activity.
The response was dose dependent.
Further, an intravenous (IV) injection of leptin (1 ng, 0.1 mL) facilitated the efferent nerve activity of the sympathetic nerve to the adrenal gland and suppressed that of the celiac branch of the vagus nerve.
In hepatic vagotomized rats, no change in efferent activity of the adrenal sympathetic nerve nor celiac branch of the vagus nerve was observed following iv administration of leptin.
These observations suggest that leptin sensors in the hepatoportal region play a role in reflex modulation of autonomic outflow in relation to metabolic functions.
American Psychological Association (APA)
Niijima, Akira. 2011. Hepatoportal Leptin Sensors and Their Reflex Effects on Autonomic Outflow in the Rat. Journal of Obesity،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-477920
Modern Language Association (MLA)
Niijima, Akira. Hepatoportal Leptin Sensors and Their Reflex Effects on Autonomic Outflow in the Rat. Journal of Obesity No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-477920
American Medical Association (AMA)
Niijima, Akira. Hepatoportal Leptin Sensors and Their Reflex Effects on Autonomic Outflow in the Rat. Journal of Obesity. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-477920
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477920