Metabolic Profiles Distinguish Non-Dampness-Phlegm and Dampness-Phlegm Patterns among Korean Patients with Acute Cerebral Infarction

Joint Authors

Ko, Mi Mi
Zhang, Chen
Jones, A. Daniel
Cha, Min Ho
Lee, Myeong Soo

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-03-14

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

Traditional Korean Medicine classifies stroke into four subtype patterns according to symptomatic pattern identification: Qi deficiency (QD), Yin deficiency (YD), Dampness-phlegm (DP), and Fire and Heat (FH).

This study investigated the difference in metabolic profiles of plasma comparing subjects displaying non-DP and DP patterns.

A total of 141 patients with cerebral infarction enrolled in this study were distributed as non-DP (N=68) and DP (N=73).

Anthropometric parameters and symptom/sign index were measured.

Metabolic profiling was performed using ultrahigh-performance liquid chromatography-mass spectrometry.

The Ratio of subjects with slippery pulse was higher in DP pattern, but fine pulse was lower than that in non-DP pattern.

As a result of metabolomics analysis, twenty-one metabolites displayed different levels between non-DP and DP patterns.

Two were identified as lysophosphatidylcholines (LPCs), LPC(18:2), and LPC(20:3) having an unsaturated acyl chain and showed lower levels in DP pattern than in non-DP pattern (P=0.015, 0.034, resp.).

However, the saturated LPCs, LPC(18:0) and LPC(16:0), exhibited slight but statistically insignificant elevation in DP pattern.

Our results demonstrated that plasma LPCs with polyunsaturated fatty acid groups were associated with DP pattern and suggest that variation of plasma lipid profiles may serve as potential biomarker for diagnosis of DP pattern.

American Psychological Association (APA)

Cha, Min Ho& Jones, A. Daniel& Ko, Mi Mi& Zhang, Chen& Lee, Myeong Soo. 2013. Metabolic Profiles Distinguish Non-Dampness-Phlegm and Dampness-Phlegm Patterns among Korean Patients with Acute Cerebral Infarction. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-477937

Modern Language Association (MLA)

Cha, Min Ho…[et al.]. Metabolic Profiles Distinguish Non-Dampness-Phlegm and Dampness-Phlegm Patterns among Korean Patients with Acute Cerebral Infarction. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-477937

American Medical Association (AMA)

Cha, Min Ho& Jones, A. Daniel& Ko, Mi Mi& Zhang, Chen& Lee, Myeong Soo. Metabolic Profiles Distinguish Non-Dampness-Phlegm and Dampness-Phlegm Patterns among Korean Patients with Acute Cerebral Infarction. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-477937

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-477937