CD24 Expression as a Marker for Predicting Clinical Outcome in Human Gliomas
Joint Authors
Wang, Tao
Deng, Jianping
Zhao, Zhenwei
Yu, Jia
Wang, Liang
Gao, Guodong
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
CD24 is overexpressed in glioma cells in vitro and in vivo.
However, the correlation of its expression with clinicopathological parameters of gliomas and its prognostic significance in this tumor remain largely unknown.
To address this problem, 151 glioma specimens and 10 nonneoplastic brain tissues were collected.
Quantitative real-time PCR, immunochemistry assay, and Western blot analysis were carried out to investigate the expression of CD24.
As per the results, CD24 was overexpressed in gliomas.
Its expression levels in glioma tissues with higher grade (P<0.001) and lower KPS (P<0.001) were significantly higher than those with lower grade and higher KPS, respectively.
Cox multifactor analysis showed that CD24 (P=0.02) was an independent prognosis factor for human glioma.
Our data provides convincing evidence for the first time that the overexpression of CD24 at gene and protein levels is correlated with advanced clinicopathological parameters and poor prognosis in patients with glioma.
American Psychological Association (APA)
Deng, Jianping& Gao, Guodong& Wang, Liang& Wang, Tao& Yu, Jia& Zhao, Zhenwei. 2012. CD24 Expression as a Marker for Predicting Clinical Outcome in Human Gliomas. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-477954
Modern Language Association (MLA)
Deng, Jianping…[et al.]. CD24 Expression as a Marker for Predicting Clinical Outcome in Human Gliomas. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-477954
American Medical Association (AMA)
Deng, Jianping& Gao, Guodong& Wang, Liang& Wang, Tao& Yu, Jia& Zhao, Zhenwei. CD24 Expression as a Marker for Predicting Clinical Outcome in Human Gliomas. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-477954
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477954