Modeling the Chemoelectromechanical Behavior of Skeletal Muscle Using the Parallel Open-Source Software Library OpenCMISS
Joint Authors
Röhrle, Oliver
Heidlauf, Thomas
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
An extensible, flexible, multiscale, and multiphysics model for nonisometric skeletal muscle behavior is presented.
The skeletal muscle chemoelectromechanical model is based on a bottom-up approach modeling the entire excitation-contraction pathway by strongly coupling a detailed biophysical model of a half-sarcomere to the propagation of action potentials along skeletal muscle fibers and linking cellular parameters to a transversely isotropic continuum-mechanical constitutive equation describing the overall mechanical behavior of skeletal muscle tissue.
Since the multiscale model exhibits separable time scales, a special emphasis is placed on employing computationally efficient staggered solution schemes.
Further, the implementation builds on the open-source software library OpenCMISS and uses state-of-the-art parallelization techniques taking advantage of the unique anatomical fiber architecture of skeletal muscles.
OpenCMISS utilizes standardized data structures for geometrical aspects (FieldML) and cellular models (CellML).
Both standards are designed to allow for a maximum flexibility, reproducibility, and extensibility.
The results demonstrate the model’s capability of simulating different aspects of nonisometric muscle contraction and efficiently simulating the chemoelectromechanical behavior in complex skeletal muscles such as the tibialis anterior muscle.
American Psychological Association (APA)
Heidlauf, Thomas& Röhrle, Oliver. 2013. Modeling the Chemoelectromechanical Behavior of Skeletal Muscle Using the Parallel Open-Source Software Library OpenCMISS. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-477966
Modern Language Association (MLA)
Heidlauf, Thomas& Röhrle, Oliver. Modeling the Chemoelectromechanical Behavior of Skeletal Muscle Using the Parallel Open-Source Software Library OpenCMISS. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-477966
American Medical Association (AMA)
Heidlauf, Thomas& Röhrle, Oliver. Modeling the Chemoelectromechanical Behavior of Skeletal Muscle Using the Parallel Open-Source Software Library OpenCMISS. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-477966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477966