Dendritic Cell-Based Immunotherapy for Prostate Cancer
Joint Authors
Zastrow, Stefan
Jähnisch, Hanka
Wehner, Rebekka
Wirth, Manfred P.
Bachmann, Michael
Schmitz, Marc
Rieber, Ernst Peter
Kiessling, Andrea
Füssel, Susanne
Source
Clinical and Developmental Immunology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Dendritic cells (DCs) are professional antigen-presenting cells (APCs), which display an extraordinary capacity to induce, sustain, and regulate T-cell responses providing the opportunity of DC-based cancer vaccination strategies.
Thus, clinical trials enrolling prostate cancer patients were conducted, which were based on the administration of DCs loaded with tumor-associated antigens.
These clinical trials revealed that DC-based immunotherapeutic strategies represent safe and feasible concepts for the induction of immunological and clinical responses in prostate cancer patients.
In this context, the administration of the vaccine sipuleucel-T consisting of autologous peripheral blood mononuclear cells including APCs, which were pre-exposed in vitro to the fusion protein PA2024, resulted in a prolonged overall survival among patients with metastatic castration-resistent prostate cancer.
In April 2010, sipuleucel-T was approved by the United States Food and Drug Administration for prostate cancer therapy.
American Psychological Association (APA)
Jähnisch, Hanka& Füssel, Susanne& Kiessling, Andrea& Wehner, Rebekka& Zastrow, Stefan& Bachmann, Michael…[et al.]. 2010. Dendritic Cell-Based Immunotherapy for Prostate Cancer. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-477992
Modern Language Association (MLA)
Jähnisch, Hanka…[et al.]. Dendritic Cell-Based Immunotherapy for Prostate Cancer. Clinical and Developmental Immunology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-477992
American Medical Association (AMA)
Jähnisch, Hanka& Füssel, Susanne& Kiessling, Andrea& Wehner, Rebekka& Zastrow, Stefan& Bachmann, Michael…[et al.]. Dendritic Cell-Based Immunotherapy for Prostate Cancer. Clinical and Developmental Immunology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-477992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477992