Decreased Expression of T-Cell Costimulatory Molecule CD28 on CD4 and CD8 T Cells of Mexican Patients with Pulmonary Tuberculosis
Joint Authors
Espinosa-Cueto, Patricia
Mancilla, Nathalie
Leyva-Meza, Rosario
Bernal-Fernandez, German
Mancilla, Raúl
Source
Tuberculosis Research and Treatment
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Patients with tuberculosis frequently develop anergy, a state of T-cell hyporesponsiveness in which defective T-cell costimulation could be a factor.
To know if the expression of T-cell costimulatory molecules was altered in tuberculosis, we analyzed the peripheral blood T-cell phenotype of 23 Mexican patients with pulmonary tuberculosis.
There was severe CD4 (P<.001) and CD8 (P<.01) lymphopenia and upregulation of costimulatory molecule CD30 on CD4 and CD8 T cells (P<.05); this increase was higher in relapsing tuberculosis.
The main finding was severe downregulation of the major costimulatory molecule CD28 on both CD8 and CD4 T cells (P<.001).
Depletion of the CD4/CD28 subset, a hitherto undescribed finding, is relevant because CD4 T cells constitute the main arm of the cell-mediated antimycobacterial immune response.
American Psychological Association (APA)
Bernal-Fernandez, German& Espinosa-Cueto, Patricia& Leyva-Meza, Rosario& Mancilla, Nathalie& Mancilla, Raúl. 2010. Decreased Expression of T-Cell Costimulatory Molecule CD28 on CD4 and CD8 T Cells of Mexican Patients with Pulmonary Tuberculosis. Tuberculosis Research and Treatment،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-477998
Modern Language Association (MLA)
Bernal-Fernandez, German…[et al.]. Decreased Expression of T-Cell Costimulatory Molecule CD28 on CD4 and CD8 T Cells of Mexican Patients with Pulmonary Tuberculosis. Tuberculosis Research and Treatment No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-477998
American Medical Association (AMA)
Bernal-Fernandez, German& Espinosa-Cueto, Patricia& Leyva-Meza, Rosario& Mancilla, Nathalie& Mancilla, Raúl. Decreased Expression of T-Cell Costimulatory Molecule CD28 on CD4 and CD8 T Cells of Mexican Patients with Pulmonary Tuberculosis. Tuberculosis Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-477998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477998