DTI and MR Volumetry of Hippocampus-PCPCC Circuit : In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease
Joint Authors
Caverzasi, E.
Palesi, F.
Vitali, P.
Chiarati, P.
Bastianello, S.
Pichiecchio, A.
Sinforiani, E.
Colli-Tibaldi, E.
D'Amore, F.
Castellazzi, G.
D'Errico, I.
Source
Neurology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hippocampal damage, by DTI or MR volumetry, and PET hypoperfusion of precuneus/posterior cingulate cortex (PC/PCC) were proposed as biomarkers of conversion from preclinical (MCI) to clinical stage of Alzheimer's disease (AD).
This study evaluated structural damage, by DTI and MR volumetry, of hippocampi and tracts connecting hippocampus to PC/PCC (hipp-PC/PCC) in 10 AD, 10 MCI, and 18 healthy controls (CTRL).
Normalized volumes, mean diffusivity (MD), and fractional anisotropy (FA) were obtained for grey matter (GM), white matter (WM), hippocampi, PC/PCC, and hipp-PC/PCC tracts.
In hippocampi and hipp-PC/PCC tracts, decreased volumes and increased MD were found in AD versus CTRL (P<.001).
The same results with lower significance (P<.05) were found in MCI versus CTRL.
Verbal memory correlated (P<.05) in AD with left hippocampal and hipp-PC/PCC tract MD, and in MCI with FA of total WM.
Both DTI and MR volumetry of hippocampi and hipp-PC/PCC tracts detect early signs of AD in MCI patients.
American Psychological Association (APA)
Palesi, F.& Vitali, P.& Chiarati, P.& Castellazzi, G.& Caverzasi, E.& Pichiecchio, A.…[et al.]. 2011. DTI and MR Volumetry of Hippocampus-PCPCC Circuit : In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease. Neurology Research International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-478025
Modern Language Association (MLA)
Palesi, F.…[et al.]. DTI and MR Volumetry of Hippocampus-PCPCC Circuit : In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease. Neurology Research International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-478025
American Medical Association (AMA)
Palesi, F.& Vitali, P.& Chiarati, P.& Castellazzi, G.& Caverzasi, E.& Pichiecchio, A.…[et al.]. DTI and MR Volumetry of Hippocampus-PCPCC Circuit : In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease. Neurology Research International. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-478025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478025
