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The Antitumor Effects of Triterpenoid Saponins from the Anemone flaccida and the Underlying Mechanism
Joint Authors
Huang, Fang
Fang, Ying
Han, Lin-Tao
Li, Ming-Ming
Yang, Hong-Bing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Anemone flaccida Fr.
Schmidt, a family of ancient hopanoids, have been used as traditional Asian herbs for the treatments of inflammation and convulsant diseases.
Previous study on HeLa cells suggested that triterpenoid saponins from Anemone flaccida Fr.
Schmidt may have potential antitumor effect due to their apoptotic activities.
Here, we confirmed the apoptotic activities of the following five triterpenoid saponins: glycoside St-I4a (1), glycoside St-J (2), anhuienoside E (3), hedera saponin B (4), and flaccidoside II (5) on human BEL-7402 and HepG2 hepatoma cell lines, as well as the model of HeLa cells treated with lipopolysaccharide (LPS).
We found that COX-2/PGE2 signaling pathway, which plays key roles in the development of cancer, is involved in the antitumor activities of these saponins.
These data provide the evidence that triterpenoid saponins can induce apoptosis via COX-2/PGE2 pathway, implying a preventive role of saponins from Anemone flaccida in tumor.
American Psychological Association (APA)
Han, Lin-Tao& Fang, Ying& Li, Ming-Ming& Yang, Hong-Bing& Huang, Fang. 2013. The Antitumor Effects of Triterpenoid Saponins from the Anemone flaccida and the Underlying Mechanism. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-478030
Modern Language Association (MLA)
Han, Lin-Tao…[et al.]. The Antitumor Effects of Triterpenoid Saponins from the Anemone flaccida and the Underlying Mechanism. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-478030
American Medical Association (AMA)
Han, Lin-Tao& Fang, Ying& Li, Ming-Ming& Yang, Hong-Bing& Huang, Fang. The Antitumor Effects of Triterpenoid Saponins from the Anemone flaccida and the Underlying Mechanism. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-478030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478030