IRAK14-Targeted Anti-Inflammatory Action of Caffeic Acid
Joint Authors
Yang, Woo Seok
Jeong, Deok
Yi, Young-Su
Cho, Jae Youl
Seo, Hyohyun
Hong, Sungyoul
Park, Jae Gwang
Moh, Sang Hyun
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Caffeic acid (CA) is a phenolic compound that is frequently present in fruits, grains, and dietary supplements.
Although CA has been reported to display various biological activities such as anti-inflammatory, anti-cancer, anti-viral, and anti-oxidative effects, the action mechanism of CA is not yet fully elucidated.
In this study, the anti-inflammatory action mechanism of CA was examined in lipopolysaccharide (LPS) treated macrophages (RAW264.7 cells) and HCl/EtOH-induced gastritis.
CA was found to diminish nitric oxide (NO) and prostaglandin E2 (PGE2) production in LPS-stimulated RAW264.7 cells.
Additionally, mRNA levels of tumor necrosis factor (TNF)-α, cyclooxygenase (COX)-2, and inducible NO synthase (iNOS) were downregulated by CA.
CA also strongly suppressed the nuclear translocation of AP-1 family proteins and the related upstream signaling cascade composed of interleukin-1 receptor-associated kinase 1 (IRAK1), IRAK4, TGF-β-activated kinase 1 (TAK1), mitogen-activated protein kinase kinase 4/7 (MKK4/7), and c-Jun N-terminal kinase (JNK).
In a direct kinase assay, CA was revealed to directly inhibit IRAK1 and IRAK4.
CA also ameliorated HCl/EtOH-induced gastric symptoms via the suppression of JNK, IRAK1, and IRAK4.
Therefore, our data strongly suggest that CA acts as an anti-inflammatory drug by directly suppressing IRAK1 and IRAK4.
American Psychological Association (APA)
Yang, Woo Seok& Jeong, Deok& Yi, Young-Su& Park, Jae Gwang& Seo, Hyohyun& Moh, Sang Hyun…[et al.]. 2013. IRAK14-Targeted Anti-Inflammatory Action of Caffeic Acid. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-478052
Modern Language Association (MLA)
Yang, Woo Seok…[et al.]. IRAK14-Targeted Anti-Inflammatory Action of Caffeic Acid. Mediators of Inflammation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-478052
American Medical Association (AMA)
Yang, Woo Seok& Jeong, Deok& Yi, Young-Su& Park, Jae Gwang& Seo, Hyohyun& Moh, Sang Hyun…[et al.]. IRAK14-Targeted Anti-Inflammatory Action of Caffeic Acid. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-478052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478052