Trypanosome Prereplication Machinery : A Potential New Target for an Old Problem

Joint Authors

da Cunha, Julia Pinheiro Chagas
Calderano, Simone Guedes
Godoy, Patricia Diogo de Melo
Elias, Maria Carolina

Source

Enzyme Research

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-05-25

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Biology

Abstract EN

Approximately ten million people suffer from Chagas disease worldwide, caused by Trypanosoma cruzi, with the disease burden predominately focused in Latin America.

Sleeping sickness is another serious health problem, caused by Trypanosoma brucei, especially in sub-Saharan countries.

Unfortunately, the drugs currently available to treat these diseases have toxic effects and are not effective against all disease phases or parasite strains.

Therefore, there is a clear need for the development of novel drugs and drug targets to treat these diseases.

We propose the trypanosome prereplication machinery component, Orc1/Cdc6, as a potential target for drug development.

In trypanosomes, Orc1/Cdc6 is involved in nuclear DNA replication, and, despite its involvement in such a conserved process, Orc1/Cdc6 is distinct from mammalian Orc1 and Cdc6 proteins.

Moreover, RNAi-mediated silencing of trypanosome Orc1/Cdc6 expression in T.

brucei decreased cell survival, indicating that Orc1/Cdc6 is critical for trypanosome survival.

American Psychological Association (APA)

Calderano, Simone Guedes& Godoy, Patricia Diogo de Melo& da Cunha, Julia Pinheiro Chagas& Elias, Maria Carolina. 2011. Trypanosome Prereplication Machinery : A Potential New Target for an Old Problem. Enzyme Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-478060

Modern Language Association (MLA)

Calderano, Simone Guedes…[et al.]. Trypanosome Prereplication Machinery : A Potential New Target for an Old Problem. Enzyme Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-478060

American Medical Association (AMA)

Calderano, Simone Guedes& Godoy, Patricia Diogo de Melo& da Cunha, Julia Pinheiro Chagas& Elias, Maria Carolina. Trypanosome Prereplication Machinery : A Potential New Target for an Old Problem. Enzyme Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-478060

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-478060