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A PEDF-Derived Peptide Inhibits Retinal Neovascularization and Blocks Mobilization of Bone Marrow-Derived Endothelial Progenitor Cells
Joint Authors
Farjo, Krysten
Ihnat, Michael
Longeras, Richard
Ma, Jian-Xing
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Proliferative diabetic retinopathy is characterized by pathological retinal neovascularization, mediated by both angiogenesis (involving mature endothelial cells) and vasculogenesis (involving bone marrow-derived circulating endothelial progenitor cells (EPCs)).
Pigment epithelium-derived factor (PEDF) contains an N-terminal 34-amino acid peptide (PEDF-34) that has antiangiogenic properties.
Herein, we present a novel finding that PEDF-34 also possesses antivasculogenic activity.
In the oxygen-induced retinopathy (OIR) model using transgenic mice that have Tie2 promoter-driven GFP expression, we quantified Tie2GFP+ cells in bone marrow and peripheral blood by fluorescence-activated cell sorting (FACS).
OIR significantly increased the number of circulating Tie2-GFP+ at P16, correlating with the peak progression of neovascularization.
Daily intraperitoneal injections of PEDF-34 into OIR mice decreased the number of Tie2-GFP+ cells in the circulation at P16 by 65% but did not affect the number of Tie2-GFP+ cells in the bone marrow.
These studies suggest that PEDF-34 attenuates EPC mobilization from the bone marrow into the blood circulation during retinal neovascularization.
American Psychological Association (APA)
Longeras, Richard& Farjo, Krysten& Ihnat, Michael& Ma, Jian-Xing. 2011. A PEDF-Derived Peptide Inhibits Retinal Neovascularization and Blocks Mobilization of Bone Marrow-Derived Endothelial Progenitor Cells. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-478082
Modern Language Association (MLA)
Longeras, Richard…[et al.]. A PEDF-Derived Peptide Inhibits Retinal Neovascularization and Blocks Mobilization of Bone Marrow-Derived Endothelial Progenitor Cells. Experimental Diabetes Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-478082
American Medical Association (AMA)
Longeras, Richard& Farjo, Krysten& Ihnat, Michael& Ma, Jian-Xing. A PEDF-Derived Peptide Inhibits Retinal Neovascularization and Blocks Mobilization of Bone Marrow-Derived Endothelial Progenitor Cells. Experimental Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-478082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478082