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TLRs, Alcohol, HCV, and Tumorigenesis
Author
Source
Gastroenterology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chronic liver damage caused by viral infection, alcohol, or obesity can result in increased risk for hepatocellular carcinoma (HCC).
Ample epidemiological evidence suggests that there is a strong synergism between hepatitis C virus (HCV) and alcoholic liver diseases (ALD).
The Toll-like receptor (TLR) signaling pathway is upregulated in chronic liver diseases.
Alcoholism is associated with endotoxemia that stimulates expression of proinflammatory cytokine expression and inflammation in the liver and fat tissues.
Recent studies of HCC have centered on cancer-initiating stem cell (CSC), including detection of CSC in cancer, identification of CSC markers, and isolation of CSC from human HCC cell lines.
Synergism between alcohol and HCV may lead to liver tumorigenesis through TLR signaling.
American Psychological Association (APA)
Machida, Keigo. 2011. TLRs, Alcohol, HCV, and Tumorigenesis. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-478100
Modern Language Association (MLA)
Machida, Keigo. TLRs, Alcohol, HCV, and Tumorigenesis. Gastroenterology Research and Practice No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-478100
American Medical Association (AMA)
Machida, Keigo. TLRs, Alcohol, HCV, and Tumorigenesis. Gastroenterology Research and Practice. 2011. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-478100
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478100