Genomics of Dementia : APOE- and CYP2D6-Related Pharmacogenetics
Joint Authors
Tellado, Iván
Lombardi, Valter R. M.
Corzo, Lola
Cacabelos, Ramón
McKay, Adam
Carril, Juan C.
Fernández-Novoa, Lucía
Leszek, Jerzy
Martínez, Rocío
Carrera, Iván
Takeda, Masatoshi
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-37, 37 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-14
Country of Publication
Egypt
No. of Pages
37
Main Subjects
Abstract EN
Dementia is a major problem of health in developed societies.
Alzheimer’s disease (AD), vascular dementia, and mixed dementia account for over 90% of the most prevalent forms of dementia.
Both genetic and environmental factors are determinant for the phenotypic expression of dementia.
AD is a complex disorder in which many different gene clusters may be involved.
Most genes screened to date belong to different proteomic and metabolomic pathways potentially affecting AD pathogenesis.
The ε4 variant of the APOE gene seems to be a major risk factor for both degenerative and vascular dementia.
Metabolic factors, cerebrovascular disorders, and epigenetic phenomena also contribute to neurodegeneration.
Five categories of genes are mainly involved in pharmacogenomics: genes associated with disease pathogenesis, genes associated with the mechanism of action of a particular drug, genes associated with phase I and phase II metabolic reactions, genes associated with transporters, and pleiotropic genes and/or genes associated with concomitant pathologies.
The APOE and CYP2D6 genes have been extensively studied in AD.
The therapeutic response to conventional drugs in patients with AD is genotype specific, with CYP2D6-PMs, CYP2D6-UMs, and APOE-4/4 carriers acting as the worst responders.
APOE and CYP2D6 may cooperate, as pleiotropic genes, in the metabolism of drugs and hepatic function.
The introduction of pharmacogenetic procedures into AD pharmacological treatment may help to optimize therapeutics.
American Psychological Association (APA)
Cacabelos, Ramón& Martínez, Rocío& Fernández-Novoa, Lucía& Carril, Juan C.& Lombardi, Valter R. M.& Carrera, Iván…[et al.]. 2012. Genomics of Dementia : APOE- and CYP2D6-Related Pharmacogenetics. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-37.
https://search.emarefa.net/detail/BIM-478114
Modern Language Association (MLA)
Cacabelos, Ramón…[et al.]. Genomics of Dementia : APOE- and CYP2D6-Related Pharmacogenetics. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-37.
https://search.emarefa.net/detail/BIM-478114
American Medical Association (AMA)
Cacabelos, Ramón& Martínez, Rocío& Fernández-Novoa, Lucía& Carril, Juan C.& Lombardi, Valter R. M.& Carrera, Iván…[et al.]. Genomics of Dementia : APOE- and CYP2D6-Related Pharmacogenetics. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-37.
https://search.emarefa.net/detail/BIM-478114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478114