Structure and Physiological Actions of Ghrelin
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-28
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
Ghrelin is a gastric peptide hormone, discovered as being the endogenous ligand of growth hormone secretagogue receptor.
Ghrelin is a 28 amino acid peptide presenting a unique n-octanoylation modification on its serine in position 3, catalyzed by ghrelin O-acyl transferase.
Ghrelin is mainly produced by a subset of stomach cells and also by the hypothalamus, the pituitary, and other tissues.
Transcriptional, translational, and posttranslational processes generate ghrelin and ghrelin-related peptides.
Homo- and heterodimers of growth hormone secretagogue receptor, and as yet unidentified receptors, are assumed to mediate the biological effects of acyl ghrelin and desacyl ghrelin, respectively.
Ghrelin exerts wide physiological actions throughout the body, including growth hormone secretion, appetite and food intake, gastric secretion and gastrointestinal motility, glucose homeostasis, cardiovascular functions, anti-inflammatory functions, reproductive functions, and bone formation.
This review focuses on presenting the current understanding of ghrelin and growth hormone secretagogue receptor biology, as well as the main physiological effects of ghrelin.
American Psychological Association (APA)
Delporte, Christine. 2013. Structure and Physiological Actions of Ghrelin. Scientifica،Vol. 2013, no. 2013, pp.1-25.
https://search.emarefa.net/detail/BIM-478117
Modern Language Association (MLA)
Delporte, Christine. Structure and Physiological Actions of Ghrelin. Scientifica No. 2013 (2013), pp.1-25.
https://search.emarefa.net/detail/BIM-478117
American Medical Association (AMA)
Delporte, Christine. Structure and Physiological Actions of Ghrelin. Scientifica. 2013. Vol. 2013, no. 2013, pp.1-25.
https://search.emarefa.net/detail/BIM-478117
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478117