Mesenchymal Progenitor Cells and Their Orthopedic Applications : Forging a Path towards Clinical Trials

Joint Authors

Luu, Hue H.
Reid, Russell R.
Luo, Qing
Zhang, Bing-Qiang
Su, Yuxi
Haydon, Rex C.
Gao, Yanhong
Huang, Enyi
Qin, Jiaqiang
Luo, Xiaoji
Gao, Jian-Li
He, Bai-Cheng
Kim, Stephanie H.
Rastegar, Farbod
Petkovic, Djuro
Shi, Qiong
Wagner, Eric R.
Bi, Yang
Zuo, Guo-Wei
Shenaq, Deana S.
Zhu, Gaohui
Chen, Liang
Yang, Ke
Luo, Jinyong
He, Tong-Chuan

Source

Stem Cells International

Issue

Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-12-16

Country of Publication

Egypt

No. of Pages

14

Main Subjects

Natural & Life Sciences (Multidisciplinary)

Abstract EN

Mesenchymal progenitor cells (MPCs) are nonhematopoietic multipotent cells capable of differentiating into mesenchymal and nonmesenchymal lineages.

While they can be isolated from various tissues, MPCs isolated from the bone marrow are best characterized.

These cells represent a subset of bone marrow stromal cells (BMSCs) which, in addition to their differentiation potential, are critical in supporting proliferation and differentiation of hematopoietic cells.

They are of clinical interest because they can be easily isolated from bone marrow aspirates and expanded in vitro with minimal donor site morbidity.

The BMSCs are also capable of altering disease pathophysiology by secreting modulating factors in a paracrine manner.

Thus, engineering such cells to maximize therapeutic potential has been the focus of cell/gene therapy to date.

Here, we discuss the path towards the development of clinical trials utilizing BMSCs for orthopaedic applications.

Specifically, we will review the use of BMSCs in repairing critical-sized defects, fracture nonunions, cartilage and tendon injuries, as well as in metabolic bone diseases and osteonecrosis.

A review of www.ClinicalTrials.gov of the United States National Institute of Health was performed, and ongoing clinical trials will be discussed in addition to the sentinel preclinical studies that paved the way for human investigations.

American Psychological Association (APA)

Shenaq, Deana S.& Rastegar, Farbod& Petkovic, Djuro& Zhang, Bing-Qiang& He, Bai-Cheng& Chen, Liang…[et al.]. 2010. Mesenchymal Progenitor Cells and Their Orthopedic Applications : Forging a Path towards Clinical Trials. Stem Cells International،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-478127

Modern Language Association (MLA)

Shenaq, Deana S.…[et al.]. Mesenchymal Progenitor Cells and Their Orthopedic Applications : Forging a Path towards Clinical Trials. Stem Cells International No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-478127

American Medical Association (AMA)

Shenaq, Deana S.& Rastegar, Farbod& Petkovic, Djuro& Zhang, Bing-Qiang& He, Bai-Cheng& Chen, Liang…[et al.]. Mesenchymal Progenitor Cells and Their Orthopedic Applications : Forging a Path towards Clinical Trials. Stem Cells International. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-478127

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-478127