Mesenchymal Progenitor Cells and Their Orthopedic Applications : Forging a Path towards Clinical Trials
Joint Authors
Luu, Hue H.
Reid, Russell R.
Luo, Qing
Zhang, Bing-Qiang
Su, Yuxi
Haydon, Rex C.
Gao, Yanhong
Huang, Enyi
Qin, Jiaqiang
Luo, Xiaoji
Gao, Jian-Li
He, Bai-Cheng
Kim, Stephanie H.
Rastegar, Farbod
Petkovic, Djuro
Shi, Qiong
Wagner, Eric R.
Bi, Yang
Zuo, Guo-Wei
Shenaq, Deana S.
Zhu, Gaohui
Chen, Liang
Yang, Ke
Luo, Jinyong
He, Tong-Chuan
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Mesenchymal progenitor cells (MPCs) are nonhematopoietic multipotent cells capable of differentiating into mesenchymal and nonmesenchymal lineages.
While they can be isolated from various tissues, MPCs isolated from the bone marrow are best characterized.
These cells represent a subset of bone marrow stromal cells (BMSCs) which, in addition to their differentiation potential, are critical in supporting proliferation and differentiation of hematopoietic cells.
They are of clinical interest because they can be easily isolated from bone marrow aspirates and expanded in vitro with minimal donor site morbidity.
The BMSCs are also capable of altering disease pathophysiology by secreting modulating factors in a paracrine manner.
Thus, engineering such cells to maximize therapeutic potential has been the focus of cell/gene therapy to date.
Here, we discuss the path towards the development of clinical trials utilizing BMSCs for orthopaedic applications.
Specifically, we will review the use of BMSCs in repairing critical-sized defects, fracture nonunions, cartilage and tendon injuries, as well as in metabolic bone diseases and osteonecrosis.
A review of www.ClinicalTrials.gov of the United States National Institute of Health was performed, and ongoing clinical trials will be discussed in addition to the sentinel preclinical studies that paved the way for human investigations.
American Psychological Association (APA)
Shenaq, Deana S.& Rastegar, Farbod& Petkovic, Djuro& Zhang, Bing-Qiang& He, Bai-Cheng& Chen, Liang…[et al.]. 2010. Mesenchymal Progenitor Cells and Their Orthopedic Applications : Forging a Path towards Clinical Trials. Stem Cells International،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-478127
Modern Language Association (MLA)
Shenaq, Deana S.…[et al.]. Mesenchymal Progenitor Cells and Their Orthopedic Applications : Forging a Path towards Clinical Trials. Stem Cells International No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-478127
American Medical Association (AMA)
Shenaq, Deana S.& Rastegar, Farbod& Petkovic, Djuro& Zhang, Bing-Qiang& He, Bai-Cheng& Chen, Liang…[et al.]. Mesenchymal Progenitor Cells and Their Orthopedic Applications : Forging a Path towards Clinical Trials. Stem Cells International. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-478127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478127