The Other T Helper Cells in Asthma Pathogenesis
Joint Authors
Vock, Christina
Hauber, Hans-Peter
Wegmann, Michael
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The complex phenotype of allergic bronchial asthma involves a variable degree of bronchoobstruction, increased mucus production, and airway remodeling.
So far it is suggested that it arises from multiple interactions of infiltrating and structural cells in the context of chronic airway inflammation that is orchestrated by T helper 2 (TH2) cells.
By secreting a plethora of typical mediators such as interleukin (IL) 4, IL-5, and IL-13, these cells hold a key position in asthma pathogenesis.
However, therapeutic approaches targeting these TH2-type mediators failed to improve asthma symptoms and impressively showed that asthma pathogenesis cannot be reduced by TH2 cell functions.
Recently, other T helper cells, that is, TH9 and TH17 cells, have been identified and these cells also contribute to asthma pathogenesis, the processes leading to formation or aggravation of asthma.
Furthermore, TH25 cells, TH3 cells, and regulatory T cells have also been implicated in asthma pathogenesis.
This paper aims at summarizing recent insights about these new T helper cells in asthma pathogenesis.
American Psychological Association (APA)
Vock, Christina& Hauber, Hans-Peter& Wegmann, Michael. 2010. The Other T Helper Cells in Asthma Pathogenesis. Journal of Allergy،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-478151
Modern Language Association (MLA)
Vock, Christina…[et al.]. The Other T Helper Cells in Asthma Pathogenesis. Journal of Allergy No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-478151
American Medical Association (AMA)
Vock, Christina& Hauber, Hans-Peter& Wegmann, Michael. The Other T Helper Cells in Asthma Pathogenesis. Journal of Allergy. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-478151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478151