Convenient Synthesis of 1,4-Dideoxy-1,4-imino-D-ribitol from D-Ribose
Joint Authors
Oba, Makoto
Kawaji, Shoi
Sano, Takanori
Nishiyama, Kozaburo
Kushima, Hironobu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
This paper describes a convenient synthesis of 1,4-dideoxy-1,4-imino-D-ribitol (DRB) from D-ribose.
L-Lyxonolactone, a key intermediate in this synthesis, was prepared by base-promoted hydrolysis of a 5-chlorinated D-ribonolactone derivative with inversion of configuration at the C-4 position.
Cyclization of the generated dimesylated L-lyxitol with benzylamine proceeded with another configurational inversion at C-4 to afford the D-ribo-configured pyrrolidine system, which upon deprotection gave DRB.
American Psychological Association (APA)
Oba, Makoto& Kawaji, Shoi& Kushima, Hironobu& Sano, Takanori& Nishiyama, Kozaburo. 2013. Convenient Synthesis of 1,4-Dideoxy-1,4-imino-D-ribitol from D-Ribose. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-478164
Modern Language Association (MLA)
Oba, Makoto…[et al.]. Convenient Synthesis of 1,4-Dideoxy-1,4-imino-D-ribitol from D-Ribose. Journal of Chemistry No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-478164
American Medical Association (AMA)
Oba, Makoto& Kawaji, Shoi& Kushima, Hironobu& Sano, Takanori& Nishiyama, Kozaburo. Convenient Synthesis of 1,4-Dideoxy-1,4-imino-D-ribitol from D-Ribose. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-478164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478164
