Stimulation-Dependent Intraspinal Microtubules and Synaptic Failure in Alzheimer's Disease : A Review
Joint Authors
Kato, Yoko
Nagao, Shizuko
Karagiozov, Kostadin
Futatsugi, Yoshio
Mitsuyama, Fuyuki
Kawase, Tsukasa
Okuya, Masato
Koide, Tadashi
Kanno, Tetsuo
Sano, Hirotoshi
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
There are many microtubules in axons and dendritic shafts, but it has been thought that there were fewer microtubules in spines.
Recently, there have been four reports that observed the intraspinal microtubules.
Because microtubules originate from the centrosome, these four reports strongly suggest a stimulation-dependent connection between the nucleus and the stimulated postsynaptic membrane by microtubules.
In contrast, several pieces of evidence suggest that spine elongation may be caused by the polymerization of intraspinal microtubules.
This structural mechanism for spine elongation suggests, conversely, that the synapse loss or spine loss observed in Alzheimer’s disease may be caused by the depolymerization of intraspinal microtubules.
Based on this evidence, it is suggested that the impairment of intraspinal microtubules may cause spinal structural change and block the translocation of plasticity-related molecules between the stimulated postsynaptic membranes and the nucleus, resulting in the cognitive deficits of Alzheimer's disease.
American Psychological Association (APA)
Mitsuyama, Fuyuki& Futatsugi, Yoshio& Okuya, Masato& Kawase, Tsukasa& Karagiozov, Kostadin& Kato, Yoko…[et al.]. 2012. Stimulation-Dependent Intraspinal Microtubules and Synaptic Failure in Alzheimer's Disease : A Review. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-478193
Modern Language Association (MLA)
Mitsuyama, Fuyuki…[et al.]. Stimulation-Dependent Intraspinal Microtubules and Synaptic Failure in Alzheimer's Disease : A Review. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-478193
American Medical Association (AMA)
Mitsuyama, Fuyuki& Futatsugi, Yoshio& Okuya, Masato& Kawase, Tsukasa& Karagiozov, Kostadin& Kato, Yoko…[et al.]. Stimulation-Dependent Intraspinal Microtubules and Synaptic Failure in Alzheimer's Disease : A Review. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-478193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478193