Bone : Incretin Hormones Perceiver or Receiver?
Joint Authors
Rotella, Carlo Maria
Mannucci, Edoardo
Dicembrini, Ilaria
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Novel incretin-based drugs, such as glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase-4 inhibitors (DPP-4i), have been last introduced in the pharmacological treatment of type 2 diabetes.
In the last few years, the interest on the relationship of gut hormones with bone metabolism in diabetes has been increasing.
The aim of present paper is to examine in vitro and in vivo evidence on the connections between incretin hormones and bone metabolism.
We also discuss results of clinical trials and metaanalysis, explore the effects of incretin drugs in vitro on osteogenic cells and osteoclasts, and speculate on the possibility of different effects of GLP-1 RA and DPP-4i on the risk of bone fractures risk in humans.
Although existing preliminary evidence suggests a protective effect on the bone, at least for DPP-4i, further controlled, long-term studies with measurement of bone markers, bone density, and clinical fractures rates are needed to substantiate and confirm those findings.
American Psychological Association (APA)
Dicembrini, Ilaria& Mannucci, Edoardo& Rotella, Carlo Maria. 2012. Bone : Incretin Hormones Perceiver or Receiver?. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-478205
Modern Language Association (MLA)
Dicembrini, Ilaria…[et al.]. Bone : Incretin Hormones Perceiver or Receiver?. Experimental Diabetes Research No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-478205
American Medical Association (AMA)
Dicembrini, Ilaria& Mannucci, Edoardo& Rotella, Carlo Maria. Bone : Incretin Hormones Perceiver or Receiver?. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-478205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478205