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The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases
Joint Authors
Pedersen, Bente Klarlund
Brandt, Claus
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Chronic inflammation is involved in the pathogenesis of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth.
Regular exercise offers protection against type 2 diabetes, cardiovascular diseases, colon cancer, breast cancer, and dementia.
Evidence suggests that the protective effect of exercise may to some extent be ascribed to the antiinflammatory effect of regular exercise.
Here we suggest that exercise may exert its anti-inflammatory effect via a reduction in visceral fat mass and/or by induction of an anti-inflammatory environment with each bout of exercise.
According to our theory, such effects may in part be mediated via muscle-derived peptides, so-called “myokines”.
Contracting skeletal muscles release myokines with endocrine effects, mediating direct anti-inflammatory effects, and/or specific effects on visceral fat.
Other myokines work locally within the muscle and exert their effects on signalling pathways involved in fat oxidation and glucose uptake.
By mediating anti-inflammatory effects in the muscle itself, myokines may also counteract TNF-driven insulin resistance.
In conclusion, exercise-induced myokines appear to be involved in mediating both systemic as well as local anti-inflammatory effects.
American Psychological Association (APA)
Brandt, Claus& Pedersen, Bente Klarlund. 2010. The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-478240
Modern Language Association (MLA)
Brandt, Claus& Pedersen, Bente Klarlund. The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-478240
American Medical Association (AMA)
Brandt, Claus& Pedersen, Bente Klarlund. The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-478240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478240