General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form
Joint Authors
Máté, Zsuzsanna
Papp, András
Kónya, Zoltán
Pusztai, Péter
Sápi, András
Nagymajtényi, László
Takács, Szabolcs
Horváth, Edina
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
In an attempt to model occupational and environmental Mn exposures and their possible interaction, young male Wistar rats were exposed to Mn by oral administration in dissolved form (MnCl2·4H2O, 14.84 and 59.36 mg/kg b.w.) and by intratracheal application of MnO2 nanoparticles (2.63 mg/kg b.w.).
After 3 and 6 weeks oral, or 3 weeks oral plus 3 weeks intratracheal, exposure, general toxicological, and electrophysiological tests were done.
Body weight gain was significantly reduced after 6 and 3 plus 3 weeks exposure, but the effect of the latter on the pace of weight gain was stronger.
Organ weights signalized systemic stress and effect on lungs.
Changes in evoked electrophysiological responses (cortical sensory evoked potential and nerve action potential) indicated that the 3 plus 3 weeks combined exposure caused equal or higher changes in the latency of these responses than 6 weeks of exposure, although the calculated summed Mn dose in the former case was lower.
The results showed the importance of the physicochemical form of Mn in determining the toxic outcome, and suggested that neurofunctional markers of Mn action may indicate the human health effect better than conventional blood Mn measurement.
American Psychological Association (APA)
Horváth, Edina& Máté, Zsuzsanna& Takács, Szabolcs& Pusztai, Péter& Sápi, András& Kónya, Zoltán…[et al.]. 2012. General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-478275
Modern Language Association (MLA)
Horváth, Edina…[et al.]. General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form. The Scientific World Journal No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-478275
American Medical Association (AMA)
Horváth, Edina& Máté, Zsuzsanna& Takács, Szabolcs& Pusztai, Péter& Sápi, András& Kónya, Zoltán…[et al.]. General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-478275
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478275