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Drosophila Models of Parkinson's Disease : Discovering Relevant Pathways and Novel Therapeutic Strategies
Joint Authors
Muñoz-Soriano, Verónica
Paricio, Nuria
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Parkinson's disease (PD) is the second most common neurodegenerative disorder and is mainly characterized by the selective and progressive loss of dopaminergic neurons, accompanied by locomotor defects.
Although most PD cases are sporadic, several genes are associated with rare familial forms of the disease.
Analyses of their function have provided important insights into the disease process, demonstrating that three types of cellular defects are mainly involved in the formation and/or progression of PD: abnormal protein aggregation, oxidative damage, and mitochondrial dysfunction.
These studies have been mainly performed in PD models created in mice, fruit flies, and worms.
Among them, Drosophila has emerged as a very valuable model organism in the study of either toxin-induced or genetically linked PD.
Indeed, many of the existing fly PD models exhibit key features of the disease and have been instrumental to discover pathways relevant for PD pathogenesis, which could facilitate the development of therapeutic strategies.
American Psychological Association (APA)
Muñoz-Soriano, Verónica& Paricio, Nuria. 2011. Drosophila Models of Parkinson's Disease : Discovering Relevant Pathways and Novel Therapeutic Strategies. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-478276
Modern Language Association (MLA)
Muñoz-Soriano, Verónica& Paricio, Nuria. Drosophila Models of Parkinson's Disease : Discovering Relevant Pathways and Novel Therapeutic Strategies. The Scientific World Journal No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-478276
American Medical Association (AMA)
Muñoz-Soriano, Verónica& Paricio, Nuria. Drosophila Models of Parkinson's Disease : Discovering Relevant Pathways and Novel Therapeutic Strategies. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-478276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478276