Comparative Effects of Verapamil, Nicardipine, and Nitroglycerin on Myocardial IschemiaReperfusion Injury
Joint Authors
Beppu, Hisashi
Imaizumi, Uno
Yui, Hitoshi
Arisaka, Hirofumi
Ito, Mitsuhiro
Furuya, Munetaka
Yoshida, Kazu-Ichi
Source
Anesthesiology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this experiment was to establish whether verapamil, nicardipine, and nitroglycerin have (1) infarct size-limiting effects and (2) antiarrhythmic effects in in vivo rabbit hearts during ischemia/reperfusion.
Rabbits received regional ischemia by 30 min of left anterior descending coronary artery occlusion followed by 3 hours of reperfusion under ketamine and xylazine anesthesia.
The animals were randomly assigned to the following 4 treatment groups: a control group, a verapamil group, a nicardipine group, and a nitroglycerin group.
A continuous infusion of verapamil, nicardipine, or nitroglycerin was initiated 5 min prior to ischemia.
Infarct size/area at risk decreased in verapamil, and nitroglycerin.
The incidence of ischemia-induced arrhythmia decreased in nicardipine, verapamil and nitroglycerin.
The incidence of reperfusion-induced arrhythmias decreased in verapamil and nitroglycerin.
From the present experimental results, verapamil and nitroglycerin rather than nicardipine did afford significant protection to the heart subjected to ischemia and reperfusion in a rabbit model.
American Psychological Association (APA)
Yui, Hitoshi& Imaizumi, Uno& Beppu, Hisashi& Ito, Mitsuhiro& Furuya, Munetaka& Arisaka, Hirofumi…[et al.]. 2011. Comparative Effects of Verapamil, Nicardipine, and Nitroglycerin on Myocardial IschemiaReperfusion Injury. Anesthesiology Research and Practice،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-478321
Modern Language Association (MLA)
Yui, Hitoshi…[et al.]. Comparative Effects of Verapamil, Nicardipine, and Nitroglycerin on Myocardial IschemiaReperfusion Injury. Anesthesiology Research and Practice No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-478321
American Medical Association (AMA)
Yui, Hitoshi& Imaizumi, Uno& Beppu, Hisashi& Ito, Mitsuhiro& Furuya, Munetaka& Arisaka, Hirofumi…[et al.]. Comparative Effects of Verapamil, Nicardipine, and Nitroglycerin on Myocardial IschemiaReperfusion Injury. Anesthesiology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-478321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478321