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Sexual Dimorphism of Cardiovascular Ischemia Susceptibility Is Mediated by Heme Oxygenase
Joint Authors
Varga, Csaba
Pintér, Zoltán
Gyöngyösi, Mariann
Ménesi, Rudolf
Kupai, Krisztina
Berkó, Anikó
Pósa, Anikó
Pálfi, György
Szabó, Renáta
Pávó, Imre
Szalai, Zita
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
We investigated the gender differences in heme-oxygenase (HO) enzyme, which produces endogenous vascular protective carbon monoxide (CO).
We studied (1) the activity and expression of HO enzymes in the left ventricle (LV) and aorta, (2) basal increase in basal blood pressure provoked by arginine vasopressine (AVP) in vivo, (3) the heart perfusion induced by AVP, (4) the ST segment depression provoked by adrenaline and 30 seconds later phentolamine, and (5) the aorta ring contraction induced by AVP in female and male Wistar rats.
We found that HO activity and the expression of HO-1 and HO-2 were increased in female rat aorta and LV.
We demonstrated that the basal blood pressure and administration of AVP provoked blood pressure response are increased in the males; the female myocardium was less sensitive towards angina.
Both differences could be aggravated by the inhibition of HO.
The aorta rings were more susceptible towards vasoconstriction by AVP in males; isolated heart perfusion decrease was higher in males.
The HO inhibition aggravated the heart perfusion in both sexes.
In conclusion, the increased HO activity and expression in females might play a role in the sexual dimorphism of cardiovascular ischemia susceptibility during the reproductive age.
American Psychological Association (APA)
Pósa, Anikó& Kupai, Krisztina& Ménesi, Rudolf& Szalai, Zita& Szabó, Renáta& Pintér, Zoltán…[et al.]. 2013. Sexual Dimorphism of Cardiovascular Ischemia Susceptibility Is Mediated by Heme Oxygenase. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-478359
Modern Language Association (MLA)
Pósa, Anikó…[et al.]. Sexual Dimorphism of Cardiovascular Ischemia Susceptibility Is Mediated by Heme Oxygenase. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-478359
American Medical Association (AMA)
Pósa, Anikó& Kupai, Krisztina& Ménesi, Rudolf& Szalai, Zita& Szabó, Renáta& Pintér, Zoltán…[et al.]. Sexual Dimorphism of Cardiovascular Ischemia Susceptibility Is Mediated by Heme Oxygenase. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-478359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478359