MicroRNA : Important Player in the Pathobiology of Multiple Myeloma
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Recent studies have revealed a pivotal role played by a class of small, noncoding RNAs, microRNA (miRNA), in multiple myeloma (MM), a plasma cell (PC) malignancy causing significant morbidity and mortality.
Deregulated miRNA expression in patient’s PCs and plasma has been associated with tumor progression, molecular subtypes, clinical staging, prognosis, and drug response in MM.
A number of important oncogenic and tumor suppressor miRNAs have been discovered to regulate important genes and pathways such as p53 and IL6-JAK-STAT signaling.
miRNAs may also form complex regulatory circuitry with genetic and epigenetic machineries, the deregulation of which could lead to malignant transformation and progression.
The translational potential of miRNAs in the clinic is being increasingly recognized that they could represent novel biomarkers and therapeutic targets.
This review comprehensively summarizes current progress in delineating the roles of miRNAs in MM pathobiology and management.
American Psychological Association (APA)
Bi, Chonglei& Chng, Wee Joo. 2014. MicroRNA : Important Player in the Pathobiology of Multiple Myeloma. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-478363
Modern Language Association (MLA)
Bi, Chonglei& Chng, Wee Joo. MicroRNA : Important Player in the Pathobiology of Multiple Myeloma. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-478363
American Medical Association (AMA)
Bi, Chonglei& Chng, Wee Joo. MicroRNA : Important Player in the Pathobiology of Multiple Myeloma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-478363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478363