STOX1 : Key Player in Trophoblast Dysfunction Underlying Early Onset Preeclampsia with Growth Retardation
Joint Authors
van Dijk, Marie
Oudejans, Cees B. M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Currently, only two preeclampsia susceptibility genes (ACVR2A, STOX1) have been identified within confirmed regions with significant genome-wide linkage, although many genetic screens in multiple populations have been performed.
In this paper, we focus on the STOX1 gene.
The epigenetic status of this gene is discussed explaining the maternal transmission of the STOX1 susceptibility allele observed in preeclamptic families.
The known upstream regulation and downstream effector genes of the transcription factor STOX1 are described.
Finally, we propose a model in which we combine the cell type-specific and allele-specific effects of STOX1.
This includes intrinsic effects (differential CpG island methylation) and extrinsic effects (regulation of effector genes).
American Psychological Association (APA)
van Dijk, Marie& Oudejans, Cees B. M.. 2010. STOX1 : Key Player in Trophoblast Dysfunction Underlying Early Onset Preeclampsia with Growth Retardation. Journal of Pregnancy،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-478379
Modern Language Association (MLA)
van Dijk, Marie& Oudejans, Cees B. M.. STOX1 : Key Player in Trophoblast Dysfunction Underlying Early Onset Preeclampsia with Growth Retardation. Journal of Pregnancy No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-478379
American Medical Association (AMA)
van Dijk, Marie& Oudejans, Cees B. M.. STOX1 : Key Player in Trophoblast Dysfunction Underlying Early Onset Preeclampsia with Growth Retardation. Journal of Pregnancy. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-478379
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478379