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The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts
Joint Authors
Manie, Serge
Pedersen, Natalie
Crimeen-Irwin, Blessing
Oliaro, Jane
Russell, Sarah M.
Gaus, Katharina
Pasam, Anupama
Williamson, David
Guillaumot, Patricia
Christansen, Dale
Ludford-Menting, Mandy J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Many infectious agents utilize CD46 for infection of human cells, and therapeutic applications of CD46-binding viruses are now being explored.
Besides mediating internalization to enable infection, binding to CD46 can directly alter immune function.
In particular, ligation of CD46 by antibodies or by measles virus can prevent activation of T cells by altering T-cell polarity and consequently preventing the formation of an immunological synapse.
Here, we define a mechanism by which CD46 reorients T-cell polarity to prevent T-cell receptor signaling in response to antigen presentation.
We show that CD46 associates with lipid rafts upon ligation, and that this reduces recruitment of both lipid rafts and the microtubule organizing centre to the site of receptor cross-linking.
These data combined indicate that polarization of T cells towards the site of CD46 ligation prevents formation of an immunological synapse, and this is associated with the ability of CD46 to recruit lipid rafts away from the site of TCR ligation.
American Psychological Association (APA)
Ludford-Menting, Mandy J.& Crimeen-Irwin, Blessing& Oliaro, Jane& Pasam, Anupama& Williamson, David& Pedersen, Natalie…[et al.]. 2011. The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts. Journal of Lipids،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-478386
Modern Language Association (MLA)
Ludford-Menting, Mandy J.…[et al.]. The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts. Journal of Lipids No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-478386
American Medical Association (AMA)
Ludford-Menting, Mandy J.& Crimeen-Irwin, Blessing& Oliaro, Jane& Pasam, Anupama& Williamson, David& Pedersen, Natalie…[et al.]. The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts. Journal of Lipids. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-478386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478386