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Interaction of Ingested Leucine with Glycine on Insulin and Glucose Concentrations
Joint Authors
Nuttall, Frank Q.
Gannon, Mary C.
Iverson, Jennifer F.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The majority of individual amino acids increase insulin and attenuate the plasma glucose response when ingested with glucose.
Objective.
To determine whether ingestion of two amino acids simultaneously, with glucose, would result in an additive effect.
Leucine (Leu) and glycine (Gly) were chosen because they were two of the most potent glucose-lowering amino acids when given individually.
Materials and Methods.
Nine subjects received test items on four separate days.
The first was a water control, then 25 g glucose, or Leu + Gly (1 mmol/kg fat-free mass each) ±25 g glucose, in random order.
Glucose, insulin, and glucagon were measured frequently for 2.5 hours.
Net areas were calculated.
Results.
The glucose area response decreased by 66%.
The insulin area response increased by 24% after ingestion of Leu + Gly + glucose compared to ingestion of glucose alone.
The decrease in glucose response was not additive; the increase in insulin response was far less than additive when compared to previously published individual amino acid results.
The glucagon concentration remained unchanged.
Conclusion.
There is an interaction between Leu and Gly that results in a markedly attenuated glucose response.
This occurred with a very modest increase in insulin response.
Changes in glucagon response could not explain the results.
The mechanism is unknown.
American Psychological Association (APA)
Iverson, Jennifer F.& Gannon, Mary C.& Nuttall, Frank Q.. 2014. Interaction of Ingested Leucine with Glycine on Insulin and Glucose Concentrations. Journal of Amino Acids،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-478393
Modern Language Association (MLA)
Iverson, Jennifer F.…[et al.]. Interaction of Ingested Leucine with Glycine on Insulin and Glucose Concentrations. Journal of Amino Acids No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-478393
American Medical Association (AMA)
Iverson, Jennifer F.& Gannon, Mary C.& Nuttall, Frank Q.. Interaction of Ingested Leucine with Glycine on Insulin and Glucose Concentrations. Journal of Amino Acids. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-478393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478393