Validated Spectrophotometric Methods for the Determination of Mycophenolate : An Anti-Neoplastic Agent in Bulk and Pharmaceutical Dosage Forms
Joint Authors
Annapurna, M. Mathrusri
Deepika, D.
Narendra, A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-07
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Three simple, precise and cost-effective spectrophotometric methods have been developed for the determination of Mycophenolate in bulk and its pharmaceutical formulations.
Mycophenolate shows λmax at 250.0 nm in zero-derivative spectrum (method A), 258.0 nm in first-derivative spectrum (method B) and method C is based on the calculation of area under curve (AUC) for analysis of Mycophenolate in the wavelength range of 240.0–260.0 nm.
The drug follows the Beer-Lambert's law in the concentration range of 1.0–150.0 μg/mL for all the methods.
The methods were validated by following the analytical performance parameters suggested by the International Conference on Harmonization.
All validation parameters were within the acceptable range.
The developed methods were successfully applied to estimate the amount of Mycophenolate in bulk and pharmaceutical dosage forms.
American Psychological Association (APA)
Narendra, A.& Deepika, D.& Annapurna, M. Mathrusri. 2012. Validated Spectrophotometric Methods for the Determination of Mycophenolate : An Anti-Neoplastic Agent in Bulk and Pharmaceutical Dosage Forms. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-478416
Modern Language Association (MLA)
Narendra, A.…[et al.]. Validated Spectrophotometric Methods for the Determination of Mycophenolate : An Anti-Neoplastic Agent in Bulk and Pharmaceutical Dosage Forms. Journal of Chemistry No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-478416
American Medical Association (AMA)
Narendra, A.& Deepika, D.& Annapurna, M. Mathrusri. Validated Spectrophotometric Methods for the Determination of Mycophenolate : An Anti-Neoplastic Agent in Bulk and Pharmaceutical Dosage Forms. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-478416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478416