Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts
Joint Authors
Kubiak, Jacek Z.
El Dika, Mohammed
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cyclin-Dependent Kinase 1 (CDK1) is the major M-phase kinase known also as the M-phase Promoting Factor or MPF.
Studies performed during the last decade have shown many details of how CDK1 is regulated and also how it regulates the cell cycle progression.
Xenopus laevis cell-free extracts were widely used to elucidate the details and to obtain a global view of the role of CDK1 in M-phase control.
CDK1 inactivation upon M-phase exit is a primordial process leading to the M-phase/interphase transition during the cell cycle.
Here we discuss two closely related aspects of CDK1 regulation in Xenopus laevis cell-free extracts: firstly, how CDK1 becomes inactivated and secondly, how other actors, like kinases and phosphatases network and/or specific inhibitors, cooperate with CDK1 inactivation to assure timely exit from the M-phase.
American Psychological Association (APA)
Kubiak, Jacek Z.& El Dika, Mohammed. 2011. Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts. Enzyme Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-478423
Modern Language Association (MLA)
Kubiak, Jacek Z.& El Dika, Mohammed. Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts. Enzyme Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-478423
American Medical Association (AMA)
Kubiak, Jacek Z.& El Dika, Mohammed. Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts. Enzyme Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-478423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478423