Molecular Alterations Associated with Osteosarcoma Development
Joint Authors
Marc, Baud’huin
Verrecchia, Franck
Heymann, Dominique
Redini, Françoise
Mori, Kanji
Ando, Kosei
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Osteosarcoma is the most frequent malignant primary bone tumor characterized by a high potency to form lung metastases which is the main cause of death.
Unfortunately, the conventional chemotherapy is not fully effective on osteosarcoma metastases.
The progression of a primary tumor to metastasis requires multiple processes, which are neovascularization, proliferation, invasion, survival in the bloodstream, apoptosis resistance, arrest at a distant organ, and outgrowth in secondary sites.
Consequently, recent studies have revealed new insights into the molecular mechanisms of metastasis development.
The understanding of the mechanism of molecular alterations can provide the identification of novel therapeutic targets and/or prognostic markers for osteosarcoma treatment to improve the clinical outcome.
American Psychological Association (APA)
Ando, Kosei& Mori, Kanji& Verrecchia, Franck& Marc, Baud’huin& Redini, Françoise& Heymann, Dominique. 2012. Molecular Alterations Associated with Osteosarcoma Development. Sarcoma،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-478425
Modern Language Association (MLA)
Ando, Kosei…[et al.]. Molecular Alterations Associated with Osteosarcoma Development. Sarcoma No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-478425
American Medical Association (AMA)
Ando, Kosei& Mori, Kanji& Verrecchia, Franck& Marc, Baud’huin& Redini, Françoise& Heymann, Dominique. Molecular Alterations Associated with Osteosarcoma Development. Sarcoma. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-478425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478425