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Modulation of Acetylation : Creating a Pro-survival and Anti-Inflammatory Phenotype in Lethal Hemorrhagic and Septic Shock
Joint Authors
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-15
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in histone and nonhistone proteins and in regulating fundamental cellular activities.
In this paper we review and discuss intriguing recent developments in the use of histone deacetylase inhibitors (HDACIs) to combat some critical conditions in an animal model of hemorrhagic and septic shock.
HDACIs have neuroprotective, cardioprotective, renal-protective, and anti-inflammatory properties; survival improvements have been significantly shown in these models.
We discuss the targets and mechanisms underlying these effects of HDACIs and comment on the potential new clinical applications for these agents in the future.
This paper highlights the emerging roles of HDACIs as acetylation modulators in models of hemorrhagic and septic shock and explains some contradictions encountered in previous studies.
American Psychological Association (APA)
Li, Yongqing& Alam, Hasan B.. 2011. Modulation of Acetylation : Creating a Pro-survival and Anti-Inflammatory Phenotype in Lethal Hemorrhagic and Septic Shock. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-478430
Modern Language Association (MLA)
Li, Yongqing& Alam, Hasan B.. Modulation of Acetylation : Creating a Pro-survival and Anti-Inflammatory Phenotype in Lethal Hemorrhagic and Septic Shock. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-478430
American Medical Association (AMA)
Li, Yongqing& Alam, Hasan B.. Modulation of Acetylation : Creating a Pro-survival and Anti-Inflammatory Phenotype in Lethal Hemorrhagic and Septic Shock. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-478430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478430