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Curcumin Protects against 1-Methyl-4-phenylpyridinium Ion- and Lipopolysaccharide-Induced Cytotoxicities in the Mouse Mesencephalic Astrocyte via Inhibiting the Cytochrome P450 2E1
Joint Authors
Xiong, Jing
Gui, Hai-Yan
Yang, Jian
Shang, Wei
Mao, Zhao
Hu, Gang
Chen, Rui-Ni
Hu, Jin-Hua
Peng, Yan
Liu, Wei
Ning, Rui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Curcumin is extracted from the rhizomes of the ginger family plant Curcuma longa L., which has a good protection for liver, kidney, and immune system.
However, there is little information about its contribution in protection of astrocytes recently.
The present study was undertaken to elucidate the protective effect of curcumin, an herbal antioxidant, on 1-methyl-4-phenylpyridinium ion- (MPP+-) and lipopolysaccharide- (LPS-) induced cytotoxicities, as well as the underlying mechanisms by using primary mouse mesencephalic astrocytes.
The results showed that curcumin protected the mesencephalic astrocytes from MPP+- and LPS-induced toxicities along with reducing reactive oxygen species (P<0.05) and maleic dialdehyde (P<0.05) sufficiently.
Moreover, curcumin significantly inhibited the cytochrome P450 2E1 (CYP2E1) expression (P<0.01 at mRNA level, P<0.05 at protein level) and its activity (P<0.05) sufficiently induced by MPP+ and LPS in the mouse mesencephalic astrocytes.
And curcumin as well as diallyl sulphide, a CYP2E1 positive inhibitor, ameliorated MPP+- and LPS-induced mouse mesencephalic astrocytes damage.
Accordingly, curcumin protects against MPP+- and LPS-induced cytotoxicities in the mouse mesencephalic astrocyte via inhibiting the CYP2E1 expression and activity.
American Psychological Association (APA)
Gui, Hai-Yan& Chen, Rui-Ni& Peng, Yan& Hu, Jin-Hua& Mao, Zhao& Ning, Rui…[et al.]. 2013. Curcumin Protects against 1-Methyl-4-phenylpyridinium Ion- and Lipopolysaccharide-Induced Cytotoxicities in the Mouse Mesencephalic Astrocyte via Inhibiting the Cytochrome P450 2E1. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-478431
Modern Language Association (MLA)
Gui, Hai-Yan…[et al.]. Curcumin Protects against 1-Methyl-4-phenylpyridinium Ion- and Lipopolysaccharide-Induced Cytotoxicities in the Mouse Mesencephalic Astrocyte via Inhibiting the Cytochrome P450 2E1. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-478431
American Medical Association (AMA)
Gui, Hai-Yan& Chen, Rui-Ni& Peng, Yan& Hu, Jin-Hua& Mao, Zhao& Ning, Rui…[et al.]. Curcumin Protects against 1-Methyl-4-phenylpyridinium Ion- and Lipopolysaccharide-Induced Cytotoxicities in the Mouse Mesencephalic Astrocyte via Inhibiting the Cytochrome P450 2E1. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-478431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478431