![](/images/graphics-bg.png)
Effect of Peptide Receptor Radionuclide Therapy on Somatostatin Receptor Status and Glucose Metabolism in Neuroendocrine Tumors : Intraindividual Comparison of Ga-68 DOTANOC PETCT and F-18 FDG PETCT
Joint Authors
Lee, Dong Soo
Prasad, Vikas
Oh, Sowon
Baum, R. P.
Source
International Journal of Molecular Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The heterogeneous nature of the neuroendocrine tumors (NET) makes it challenging to find one uniformly applicable management protocol which is especially true for diagnosis.
The discovery of the overexpression of somatostatin receptors (SMS-R) on neuroendocrine tumor cells lead to the generalized and rapid acceptance of radiolabeled somatostatin receptor analogs for staging and restaging of NET as well as for Peptide Receptor Radionuclide Therapy (PRRNT) using Y-90 and Lu-177 DOTATATE/DOTATOC.
In this present work we tried to look in to the effect of PRRNT on the glucose metabolism assessed by F-18 FDG PET/CT and SMS-R density assessed by Ga-68 DOTANOC PET/CT.
We observed a complex relationship between the somatostatin receptor expression and glucose metabolism with only 56% (77/138) of the lesions showing match, while the others show mismatch between the receptor status and metabolism.
The match between receptor expression and glucose metabolism increases with the grade of NET.
In grade 3 NET, there is a concurrence between the changes in glucose metabolism and somatostatin receptor expression.
PRRNT was found to be more effective in lesions with higher receptor expression.
American Psychological Association (APA)
Oh, Sowon& Prasad, Vikas& Lee, Dong Soo& Baum, R. P.. 2011. Effect of Peptide Receptor Radionuclide Therapy on Somatostatin Receptor Status and Glucose Metabolism in Neuroendocrine Tumors : Intraindividual Comparison of Ga-68 DOTANOC PETCT and F-18 FDG PETCT. International Journal of Molecular Imaging،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-478499
Modern Language Association (MLA)
Oh, Sowon…[et al.]. Effect of Peptide Receptor Radionuclide Therapy on Somatostatin Receptor Status and Glucose Metabolism in Neuroendocrine Tumors : Intraindividual Comparison of Ga-68 DOTANOC PETCT and F-18 FDG PETCT. International Journal of Molecular Imaging No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-478499
American Medical Association (AMA)
Oh, Sowon& Prasad, Vikas& Lee, Dong Soo& Baum, R. P.. Effect of Peptide Receptor Radionuclide Therapy on Somatostatin Receptor Status and Glucose Metabolism in Neuroendocrine Tumors : Intraindividual Comparison of Ga-68 DOTANOC PETCT and F-18 FDG PETCT. International Journal of Molecular Imaging. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-478499
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478499